|
KMID : 1134819990280020444
|
|
Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 2 p.444 ~ p.451
|
|
|
The Radioprotective Effects of Sam - Ryung - Baek - Chul - San (San - Ling - Bai - Shu - San) as a Prescriptions of Traditional Chinese Medicine in Irradiated Mice
|
|
Lee Song-Eun
Oh Heon
Yang Jung-Ah
Chung Chi-Young
Jang Jong-Sik
Jo Sung-Kee
Byun Myung-Woo
Kim Seong-Ho
|
|
|
Abstract
|
|
|
|
We performed this study to determine the radioprotective effect of Sam-Ryung-Baek-Chul-San (San-Ling-Bai-Shu-San), as a prescription of traditional Oriental medicine, and its major ingredients. Jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in irradiated mice with high and low dose of γ-rays. Sam-Ryung-Baek-Chul-San administration before irradiation increased the formation of endogenous spleen colony(p＜0.05) and reduced the frequency of radiation-induced apoptosis(p＜0.05). In the experiment on the effect of ingredients of Sam-Ryung-Baek-Chul-San, the result indicated that the extracts of Panax ginseng, Poria cocos and Coix lacryma-jabi might have the major radioprotective effects. Although the mechanisms of these inhibitory effects remain to be elucidated, these results indicated that Sam-Ryung-Baek-Chul-San might be a useful radioprotector, especially since it is a relatively nontoxic natural product.
|
|
|
KEYWORD
|
|
|
radioprotective, Sam-Ryung-Baek-Chul-San(San-Ling-Bai-Shu-San), Oriental medicine, jejunal crypt, spleen
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|